(C) Cell wound scratch assay of HCT116, HCT-8, and SW620 cells treated withĬOMP siRNA or COMP overexpression vectors. (B) WB analysis ofĬOMP and EMT-related markers in HCT116 cells under COMP knockdown or overexpression. (A) Cell phenotypic changes in cells treated with COMP siRNA and COMP overexpression. Organismal Systems > Digestive system > Gastric acid secretion.įigure 4.Organismal Systems > Endocrine system > Oxytocin signaling pathway.Organismal Systems > Endocrine system > Thyroid hormone signaling pathway.Organismal Systems > Immune system > Leukocyte transendothelial migration.Organismal Systems > Immune system > Platelet activation.Human Diseases > Cardiovascular diseases > Viral myocarditis.Human Diseases > Cardiovascular diseases > Dilated cardiomyopathy (DCM).Human Diseases > Cardiovascular diseases > Arrhythmogenic right ventricular cardiomyopathy (ARVC).Human Diseases > Cardiovascular diseases > Hypertrophic cardiomyopathy (HCM).Human Diseases > Cancers: Specific types > Hepatocellular carcinoma.Human Diseases > Cancers: Overview > Proteoglycans in cancer.Human Diseases > Infectious diseases: Viral > Influenza A.Human Diseases > Infectious diseases: Bacterial > Salmonella infection.Human Diseases > Infectious diseases: Bacterial > Shigellosis.Human Diseases > Infectious diseases: Bacterial > Pathogenic Escherichia coli infection.Human Diseases > Infectious diseases: Bacterial > Vibrio cholerae infection.Human Diseases > Infectious diseases: Bacterial > Bacterial invasion of epithelial cells.Environmental Information Processing > Signal transduction > Hippo signaling pathway.Environmental Information Processing > Signal transduction > Rap1 signaling pathway.Cellular Processes > Cell motility > Regulation of actin cytoskeleton.Cellular Processes > Cellular community - eukaryotes > Tight junction.Cellular Processes > Cellular community - eukaryotes > Adherens junction.Cellular Processes > Cellular community - eukaryotes > Focal adhesion.Cellular Processes > Cell growth and death > Apoptosis.Cellular Processes > Transport and catabolism > Phagosome.The toxin can be highly efficient at very low concentrations by acting on formin homology family proteins: toxic actin oligomers bind with high affinity to formins and adversely affect both nucleation and elongation abilities of formins, causing their potent inhibition in both profilin-dependent and independent manners. (Microbial infection) Monomeric actin is cross-linked by V.cholerae toxins RtxA and VgrG1 in case of infection: bacterial toxins mediate the cross-link between Lys-50 of one monomer and Glu-270 of another actin monomer, resulting in formation of highly toxic actin oligomers that cause cell rounding. In contrast, filament nucleation by the Arp2/3 complex is not affected. N-terminal acetylation by NAA80 affects actin filament depolymerization and elongation, including elongation driven by formins. Methylation at His-73 is required for smooth muscle contraction of the laboring uterus during delivery (By similarity). Demethylation by ALKBH4 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration. Monomethylation at Lys-84 (K84me1) regulates actin-myosin interaction and actomyosin-dependent processes. The (R)-S-oxide form is reverted by MSRB1 and MSRB2, which promote actin repolymerization. MICAL1 and MICAL2 produce the (R)-S-oxide form. Oxidation of Met-44 and Met-47 by MICALs (MICAL1, MICAL2 or MICA元) to form methionine sulfoxide promotes actin filament depolymerization.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |